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MILLS, GORDON B

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Item Type	Name
Academic Article	Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Academic Article	ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.
Academic Article	Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Academic Article	The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Academic Article	A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Academic Article	Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
Academic Article	Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Academic Article	Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
Academic Article	CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
Academic Article	Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.
Academic Article	Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
Academic Article	High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Academic Article	Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
Concept	Cell Line, Tumor
Academic Article	ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Academic Article	PTK6 regulates IGF-1-induced anchorage-independent survival.
Academic Article	A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.
Academic Article	A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes.
Academic Article	LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
Academic Article	Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.
Academic Article	Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
Academic Article	Genome-wide transcriptome profiling of homologous recombination DNA repair.
Academic Article	Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Academic Article	Unraveling the regulatory connections between two controllers of breast cancer cell fate.
Academic Article	Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
Academic Article	Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.
Academic Article	A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.
Academic Article	Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Academic Article	Functional consequence of the MET-T1010I polymorphism in breast cancer.
Academic Article	Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
Academic Article	Determinants of rapamycin sensitivity in breast cancer cells.
Academic Article	Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Academic Article	An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.
Academic Article	Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Academic Article	Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Academic Article	Pharmacodynamic markers of perifosine efficacy.
Academic Article	The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Academic Article	Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Academic Article	Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Academic Article	Vimentin is a novel AKT1 target mediating motility and invasion.
Academic Article	Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.
Academic Article	ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Academic Article	Androgen regulation of 5a-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.
Academic Article	Detection algorithm for the validation of human cell lines.
Academic Article	MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
Academic Article	Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
Academic Article	Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Academic Article	Systematic identification of combinatorial drivers and targets in cancer cell lines.
Academic Article	Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.
Academic Article	Modeling precision treatment of breast cancer.
Academic Article	Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations.
Academic Article	Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Academic Article	Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Academic Article	mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Academic Article	Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages.
Academic Article	Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Academic Article	Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
Academic Article	Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Academic Article	Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Academic Article	The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Academic Article	Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
Academic Article	A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.
Academic Article	Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
Academic Article	A sequence-based survey of the complex structural organization of tumor genomes.
Academic Article	Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.
Academic Article	Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Academic Article	Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Academic Article	Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
Academic Article	Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Academic Article	miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells.
Academic Article	Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Academic Article	Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set.
Academic Article	Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
Academic Article	Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Academic Article	Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
Academic Article	Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.
Academic Article	MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.
Academic Article	Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
Academic Article	Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.
Academic Article	PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors.
Academic Article	Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
Academic Article	Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Academic Article	Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.
Academic Article	EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol.
Academic Article	Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Academic Article	Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.
Academic Article	Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.
Academic Article	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.
Academic Article	Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.
Academic Article	Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Academic Article	A genetically defined model for human ovarian cancer.
Academic Article	Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Academic Article	A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Academic Article	ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.
Academic Article	Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
Academic Article	Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Academic Article	BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Academic Article	Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Academic Article	Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Academic Article	Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Academic Article	A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Academic Article	A novel AKT3 mutation in melanoma tumours and cell lines.
Academic Article	A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Academic Article	Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
Academic Article	Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.
Academic Article	Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
Academic Article	Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Academic Article	PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.
Academic Article	Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Academic Article	Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.
Academic Article	Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.
Academic Article	A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Academic Article	Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis.
Academic Article	A time-series DDP for functional proteomics profiles.
Academic Article	Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Academic Article	MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.
Academic Article	Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Academic Article	AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
Academic Article	Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
Academic Article	An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Academic Article	EVI1 splice variants modulate functional responses in ovarian cancer cells.
Academic Article	Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.
Academic Article	Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer.
Academic Article	A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Academic Article	Perturbation biology: inferring signaling networks in cellular systems.
Academic Article	A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.
Academic Article	Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
Academic Article	Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Academic Article	Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
Academic Article	A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Academic Article	Systematic analysis of genotype-specific drug responses in cancer.
Academic Article	Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected].
Academic Article	Bayesian inference of signaling network topology in a cancer cell line.
Academic Article	Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis.
Academic Article	BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Academic Article	MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Academic Article	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Academic Article	Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Academic Article	Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line.
Academic Article	Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Academic Article	Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
Academic Article	Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.
Academic Article	Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Academic Article	Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Academic Article	AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Academic Article	Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.
Academic Article	Subtype and pathway specific responses to anticancer compounds in breast cancer.
Academic Article	Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.
Academic Article	Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Academic Article	Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
Academic Article	Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.
Academic Article	YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.
Academic Article	Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
Academic Article	A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.
Academic Article	Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Academic Article	Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis.
Academic Article	Peroxiredoxin-1 protects estrogen receptor a from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Academic Article	The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Academic Article	PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Academic Article	Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.
Academic Article	Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.
Academic Article	Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma.
Academic Article	Spatial normalization of reverse phase protein array data.
Academic Article	a-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.
Academic Article	Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
Academic Article	Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance.
Academic Article	Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
Academic Article	ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.
Academic Article	Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Academic Article	Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.
Academic Article	Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.
Academic Article	The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Academic Article	Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Academic Article	A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
Academic Article	Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines.
Academic Article	Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Academic Article	Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
Academic Article	Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
Academic Article	Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Academic Article	mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
Academic Article	Functional annotation of rare gene aberration drivers of pancreatic cancer.
Academic Article	BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System.
Academic Article	Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Academic Article	Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
Academic Article	Role of RPL39 in Metaplastic Breast Cancer.
Academic Article	Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.
Academic Article	Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Academic Article	Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Academic Article	A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
Academic Article	Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Academic Article	PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Academic Article	The ErbB2?Ex16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
Academic Article	Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer.
Academic Article	Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types.
Academic Article	Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Academic Article	Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.
Academic Article	Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.
Academic Article	AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Academic Article	High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype.
Academic Article	Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.
Academic Article	Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Academic Article	Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Academic Article	Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p.
Academic Article	Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.
Academic Article	Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.
Academic Article	Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.
Academic Article	YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.
Academic Article	ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.
Academic Article	Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer.
Academic Article	PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Academic Article	Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma.
Academic Article	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.
Academic Article	A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Academic Article	A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors.
Academic Article	ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Academic Article	Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
Academic Article	Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies.
Academic Article	BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
Academic Article	EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
Academic Article	ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.
Academic Article	Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo.
Academic Article	Rab25 augments cancer cell invasiveness through a ?1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
Academic Article	Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article	Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2a-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression.
Academic Article	Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.
Academic Article	Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.
Academic Article	BRD4 facilitates replication stress-induced DNA damage response.
Academic Article	The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
Academic Article	RNA editing derived epitopes function as cancer antigens to elicit immune responses.
Academic Article	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.
Academic Article	Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Academic Article	?-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
Academic Article	Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.
Academic Article	BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.
Academic Article	Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Academic Article	Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Academic Article	Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer.
Academic Article	Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Academic Article	PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness.
Academic Article	Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.
Academic Article	Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.
Academic Article	Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.
Academic Article	AKT isoform-specific expression and activation across cancer lineages.
Academic Article	Prospective Clinical Sequencing of Adult Glioma.
Academic Article	GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and ?-catenin activity.
Academic Article	In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
Academic Article	Next-generation characterization of the Cancer Cell Line Encyclopedia.
Academic Article	The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Academic Article	Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Academic Article	Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Academic Article	COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms.
Academic Article	Comprehensive characterization of circular RNAs in ~?1000 human cancer cell lines.
Academic Article	Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer.
Academic Article	A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis.
Academic Article	miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer.
Academic Article	Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer.
Academic Article	Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.
Academic Article	Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
Academic Article	Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays.
Academic Article	Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Academic Article	p85? regulates autophagic degradation of AXL to activate oncogenic signaling.
Academic Article	Systems approach to rational combination therapy: PARP inhibitors.
Academic Article	MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.
Academic Article	Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
Academic Article	Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Academic Article	RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
Academic Article	Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma.
Academic Article	Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling.
Academic Article	Transient commensal clonal interactions can drive tumor metastasis.
Academic Article	Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.
Academic Article	Hormonal modulation of ESR1 mutant metastasis.
Academic Article	Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Academic Article	Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Academic Article	TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.
Academic Article	CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models.
Academic Article	A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.
Academic Article	BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators.
Academic Article	Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma.
Academic Article	WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Academic Article	Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Academic Article	PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia.
Academic Article	A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.
Academic Article	HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors.
Academic Article	BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer.
Academic Article	Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity.

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